Top: Azithromycin inside the tunnel of the cut (along the tunnel) 50S subunit from Deinococus radiodurans. Bottom: ABT-773 (ketolide) blocks the Tunnel of the 50S. The first structural data of bound azalides and ketolides, new groups based on the macrolide-antibiotics, publishe in the march 2003 isuue of Struture. (see list of publications)