The first structure based evidence of dynamic inside the tunnel of the large ribosomal subunit.
Left: The well known 'tunnel-view'. Right: Both conformations of the L22 hairpin-loop (native = yellow and troleandomycin induced flipped L22 in red) together with troleandomycin (orange) and a fictive poly peptide chain (green), without surrounding RNA.

Published in Nature Structural Biology (may, 2003). PDF there or via our (list of publications)