Publikationsliste Joerg M. Harms

2008

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Wilson D.N.*, Schluenzen F.*, Harms J.M.*, Starosta A.L., Connell S.R. and Fucini P. (2008) The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning. PNAS, online 29.Aug.2008. Print: September 9, 2008 vol. 105 no. 36 13339-13344

Harms J.M.*, Wilson D.N.*, Schluenzen F.*, Connell S.R., Stachelhaus T., Zaborowska Z., Spahn C.M.T. and Fucini P. (2008) Translational regulation via L11: Molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Molecular Cell, 30(1):26-38
Cover illustration by J.M. Harms

F. Van Bambeke, J.M. Harms, Y. Van Laethem, and Paul M. Tulkens. Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections. Expert Opin Pharmacother. 2008 Feb;9(2):267-283 (2008)

2007

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Kaminishi T.*, Wilson DN.* , Takemoto C.*, Harms JM.*, Kawazoe M., Schluenzen F., Hanawa-Suetsugu K., Shirouzu M., Fucini P. and Yokoyama S. A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction. Structure. 2007 Mar;15(3):289-97.
Cover illustration by J.M. Harms

2006

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Schluenzen F, Takemoto C, Wilson DN, Kaminishi T, Harms JM, Hanawa-Suetsugu K, Szaflarski W, Kawazoe M, Shirouzu M, Nierhaus KH, Yokoyama S, Fucini P. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8. Epub 2006 Sep 24.
Cover idea by J.M. Harms and D.N. Wilson

2005

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Wilson DN, Harms JM, Nierhaus KH, Schlünzen F and Fucini P. Species-specific antibiotic-ribosome interactions: implications for drug development. Biological Chemistry, 386, 12, Dec. 2005.
Cover illustration by J.M. Harms

Schlünzen F., Wilson DN., Tian P, Harms JM, McInnes S, Hansen H, Albrecht R, Buerger J, Wilbanks S, Fucini P. The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction. Structure (Camb). 2005 Nov;13(11):1685-94.

M. Diaconu, U. Kothe, F. Schlünzen, N. Fischer, J.M. Harms, A.G. Tonevitski, H. Stark, M.V. Rodnina and M.C. Wahl. Structural Basis for the Function of the Ribosomal L12 Stalk in Factor Binding and Activation of GTP Hydrolysis, Cell. Jul 1;121(7):991-1004 (2005).

M. Amit, R. Berisio, D. Baram, J. Harms, A. Bashan and A. Yonath. A crevice adjoining the ribosome tunnel: Hints for cotranslational folding Uncorrected Proof. FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23

D. N. Wilson*, F. Schluenzen*, J.M. Harms*, R. Albrecht, J. Buerger, T. Yoshida, T. Ohkubo, Y. Kobayashi and P. Fucini. The ribosome recycling factor interacts exclusively with ribosomal elements associated with tRNA binding and translocation. EMBO J. 24: 251-260 (2005); advance online publication, December 23, 2004.

2004

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F. Schlünzen, E. Pyetan, P. Fucini, A. Yonath and J.M. Harms. Inhibition of Peptide Bond Formation by Pleuromutilins: the Structure of the 50S Ribosomal Subunit from Deinococcus radiodurans in Complex with Tiamulin. Molecular Microbiology, Mol. Microbiology, 54(5), 1287-1294 (2004).

J.M. Harms*, F. Schlünzen*, P. Fucini, H. Bartels and A.E. Yonath. Alterations at the petidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin. BMC Biology, 2:4 (2004).

I. Agmon, M. Amit, T. Auerbach, A. Bashan, D. Baram, H. Bartels, R. Berisio, I. Greenberg, J. Harms, H.A.S. Hansen, M. Kessler, E. Pyetan, F. Schluenzen, A. Yonath and R. Zarivach. Ribosomal crystallography: a flexible nucleotide anchoring tRNA translocation facilitates peptide bond formation, chirality discrimination and antibiotics synergism. FEBS Lett 567, 20-6 (2004).

R. Zarivach, A. Bashan, R. Berisio, J.Harms, T. Auerbach, F. Schluenzen, H. Bartels, D. Baram, E. Pyetan, A. Sittner, M. Amit, H.A.S. Hansen, M. Kessler, C. Liebe, A. Wolff, I. Agmon, and A. Yonath. Functional aspects of ribosomal architecture: symmetry, chirality and regulation. J Phys Org Chem (2004).

2003

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I. Agmon, T. Auerbach, D. Baram, H. Bartels, A. Bashan, R. Berisio, P. Fucini, H.A.S. Hansen, J. Harms, M. Kessler, M. Peretz, F. Schluenzen, A. Yonath and R. Zarivach. On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes. Eur J Biochem, 270, 2543-56 (2003).

R. Berisio, J. Harms, F. Schluenzen, R. Zarivach, H. A.S. Hansen, P. Fucini and A. Yonath. Structural insight into the antibiotic action of telithromycin on resistant mutants. J. Bacteriol, 185, 4276-9 (2003).

R. Berisio, F. Schluenzen, J. Harms, A. Bashan, T. Auerbach, D. Baram and A. Yonath. Structural insight into the role of the ribosomal tunnel in cellular regulation. Nat Struct Biol, 10, 366-70 (2003).

F. Schluenzen*, J.M. Harms*, F. Franceschi, H. A.S. Hansen, H. Bartels, R. Zarivach and A. Yonath. Structural basis for the antibiotic activity of ketolides and azalides, Structure. 11, 329-38 (2003).

J.M. Harms, H. Bartels, F. Schluenzen, and A. Yonath. Antibiotics acting on the translational machinery. J Cell Sci, 116, 1391-93 (2003).
Poster idea, concept and illustration: JMH.

A. Bashan, R. Zarivach, F. Schluenzen, I. Agmon, J. Harms, T. Auerbach, D. Baram, R. Berisio, H. Bartels, H. A.S. Hansen, P. Fucini, D. Wilson, M. Peretz, M. Kessler and A. Yonath. Ribosomal crystallography: peptide bond formation and its inhibition, Biopolymers. 70,19-41 (2003).

A. Bashan, I. Agmon, R. Zarivach, F. Schluenzen, J. Harms, R. Berisio, H. Bartels, F. Franceschi, T. Auerbach, H.A.S. Hansen, E. Kossoy, M. Kessler and A. Yonath. Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression. Mol Cell, 11, 91-102 (2003).

2002

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T. Auerbach, A. Bashan, J. Harms, F. Schluenzen, R. Zarivach, H. Bartels, I. Agmon, M. Kessler, M. Pioletti, F. Franceschi and A. Yonath. Antibiotics Targeting Ribosomes: Crystallographic Studies. Current Drug Targets - Infectious Disorders, Vol 2, 169-86 (2002).
Cover illustration by J.M. Harms.

R. Zarivach*, A. Bashan*, F. Schluenzen, J. Harms, M. Pioletti, F. Franceschi and A. Yonath. Initiation and Inhibition of Protein Biosynthesis - Studies at High Resolution. Current Protein and Peptide Science, 3, 55-65, (2002).
Cover illustration by J.M. Harms

J. Harms, F. Schlünzen, R. Zarivach, A. Bashan, H. Bartels, I. Agmon and A. Yonath. Protein structure: experimental and theoretical aspects. FEBS Lett. 525, 176-178 (2002).

2001

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M. Gluehmann*, R. Zarivach*, A. Bashan, J. Harms ,F. Schluenzen, H. Bartels, I. Agmon, G. Rosenblum, M. Pioletti, T. Auerbach, H. Avila, H.A.S. Hansen , F. Franceschi and A. Yonath. Ribosomal Crystallography: From poorly diffracting micro-crystals to high resolution structures. Methods, 25, 292-302 (2001).

J. Harms*, R. Zarivach*, F. Schluenzen*, A. Bashan, S. Gat, I. Agmon, H. Bartels, F. Franceschi & A. Yonath. High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell, 107, 679-688 (2001).

F. Schluenzen*, R. Zarivach*, J. Harms*, A. Bashan, A. Tocilj, R. Albrecht, A. Yonath and F. Franceschi. Structural basis for the interaction of antibiotics with the peptidyl transferase center in eubacteria. Nature, 413, 814-821 (2001).
Cover illustration by J.M. Harms

M. Pioletty*, F. Schluenzen*, J. Harms*, M. Gluehmann, R. Zarivach, A. Bashan, H. Bartels, T. Auerbach, F. Franceschi and A.Yonath. The crystal structure of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J., 20, 1829-1839 (2001).

A. Bashan, I. Agmon, R. Zarivach, F. Schluenzen, J. Harms, M. Pioletti, H. Bartels, M. Gluehmann, H.A.S. Hansen, T. Auerbach, F. Franceschi and A. Yonath. High resolution structures of ribosomal subunits: initiation, inhibition and conformational variability. Cold Spring Harbor Symposium 66, 43-55 (2001).

D. Janell, A. Tocilj, I. Koelln, F. Schluenzen, M. Gluehmann, H.A.S. Hansen, J. Harms, A. Bashan, I. Agmon, H. Bartels, M. Kessler, H. Bartels, S. Weinstein, F. Franceschi and A. Yonath. Ribosomal crystallography and heteropoly-tungsates in Polyoxometalane Chemistry. M.T. Pope and A. Müller (eds.), 391-415, (2001).

2000

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F. Schluenzen*, A. Tocilj*, R. Zarivach, J. Harms, M. Gluehmann, D. Janell, A. Bashan, H. Bartels, I. Agmon, F. Franceschi & A. Yonath. Structure of a functionally activated small ribosomal subunit at 3.3 A resolution. Cell, 102, 615-623 (2000).

H. Bartels, M. Gluehmann, D. Janell, F. Schluenzen, A. Tocilj, A. Bashan, J. Harms, I. Levin, H.A.S. Hansen, M. Kessler, M. Pioletti, T. Auerbach, I. Agmon, W.S. Bennett, F. Franceschi and A. Yonath. Targeting exposed RNA regions in crystals of small ribosomal subunits at medium resolution. Cell Mol Biol (Noisy-le-grand),46(5), 871-82 (2000).

A. Bashan, M. Pioletti, H. Bartels, D. Janell, F. Schluenzen, M. Gluehmann, I. Levin, J. Harms, H.A.S. Hansen, A. Tocilj, T. Auerbach, H. Avila, M. Simitsopoulou, M. Peretz, W.S. Bennett, I. Agmon, M. Kessler, S. Weinstein, F. Franceschi and A. Yonath. Identification of selected ribosomal components in crystallographic maps of prokaryotic ribosomal subunits at medium resolution. In: "The Ribosome: Structure, Function, Antibiotics And Cellular Interactions", ( R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore and H.F. Noller Eds.), ASM Press, Washington, DC., 21-33 (2000).

1992-1999

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A. Tocilj*, F. Schluenzen*, H.A.S. Hansen, A. Bashan, D. Janell, M. Gluehmann, H. Bartels, J. Harms, I. Agmon, F. Franceschi, and A. Yonath. The small ribosomal subunit from Thermus thermophilus at 4.5 A resolution: Pattern fittings and the identification of a functional site. Proc NatlAcad Sci USA, 96, 14252-7 (1999).

S. Weinstein, W. Jahn, C. Glotz, F. Schluenzen, I. Levin, D. Janell, J. Harms, I. Koelln, H.A.S. Hansen, M. Gluehmann, W.S. Bennett, H. Bartels, A. Bashan, I. Agmon, M. Kessler, M. Pioletti, H. Avila, K. Anagnostopoulos, M. Peretz, T. Auerbach, F. Franceschi and A. Yonath. Metal compounds as tools for the construction and the interpretation of medium-resolution maps of ribosomal particles. J. Structural Biology, 127, 141-151 (1999).

F. Schluenzen, I. Kölln, D. Janell, M. Gluehmann, I. Levin, A. Bashan, J. Harms, H. Bartels, T. Auerbach, M. Pioletti, H. Avila, K. Anagnostopoulos, H.A.S. Hansen, W.S. Bennett, I. Agmon, M. Kessler, A. Tocilj, M. Peretz, S. Weinstein, F. Franceschi and A. Yonath. Identification of selected components in electron density maps of prokaryotic ribosome at 7 A resolution. J. Synchrotron Radiation. 6, 928-941 (1999).

J. Harms*, A. Tocilj*, I. Levin*, I. Agmon, H. Stark, I. Koelln, M. van Heel, M. Cuff, F. Schluenzen, A. Bashan, F. Franceschi, and A. Yonath. Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and X-ray crystallograhy. Structure 7, 931-41, (1999).

A. Yonath, J. Harms, H.A.S. Hansen, A. Bashan, F. Schluenzen, I. Levin, I. Koelln, A. Tocilj, I. Agmon, M. Peretz, H. Bartels, W. S. Bennett, S. Krumbholz, D. Janell, S. Weinstein, T. Auerbach, H. Avila, M. Piolleti, S. Morlang, and F. Franceschi. Crystallographic studies on the ribosome, a large macromolecular assembly exhibiting severe nonisomorphism, extreme beam sensitivity and no internal symmetry. Acta Crystallogr A, 54, 945-55 (1998).

S. Krumbholz, F. Schluenzen, J. Harms, H. Bartels, I. Koelln, K. Knaack, W.S. Bennett, P. Bhanumoorthy, H.A.S. Hansen, N. Volkmann, A. Bashan, I. Levin, A. Tocilj and A. Yonath. Ribosomal Crystallography, Cryo Protectants and Cooling Agents. Periodicum Biologorum, 100 S2, 119-125 (1998).

I. Agmon, H. Bartels, A. Bashan, W.S. Bennett, Z. Berkovitch-Yellin, N. Boeddeker, A. Dribin, M. Eisenstein, F. Franceschi, H.A.S. Hansen, J.Harms, W. Jahn, S. Krumbholz, I. Levin, M. Malemud, S. Morlang, M. Peretz, I. Sagi, F. Schluenzen, R. Sharon, J. Thygesen, N. Volkmann, V. Weinrich, S. Weinstein and A. Yonath. Crystallography, biochemistry and genetics of halophilic and thermophilic ribosomes. In: "Supramolecular Structure and Function", (G. Pifat, Ed.), 5, 155, Balaban Press, Rehovot, (1997).

J.Thygesen, S.Krumbholz, I.Levin, A.Zaytzev-Bashan, J.Harms, H.Bartels, F.Schluenzen, H.A.S.Hansen, W.S. Bennett, N. Volkmann, I. Agmon, M. Eisenstein, A. Dribin, E. Maltz, I. Sagi, S. Morlang, M. Fua, F. Franceschi, S. Weinstein, N. Böddeker, R. Sharon, K. Anagnostopoulos, M. Peretz, M. Geva, Z. Berkovitch-Yellin & A.Yonath. Ribosomal crystallography: From crystal growth to initial phasing. J. Crystal Growth, 168, 308-323 (1996)

F. Franceschi, S. Weinstein, I. Sagi, M. Peretz, V. Weinrich, S. Morlang, N. Boeddeker, M. Geva, I. Levin, I. Agmon, Z. Berkovitch-Yellin, F. Schluenzen, H. A. S. Hansen, H. Bartels, W. S. Bennett, N. Volkmann, J. Thygesen, J. Harms, A. Zaytzev-Bashan, S. Krumbholz, R. Sharon, A. Dribin, E. Maltz and A.Yonath. The combination of functional, genetics, biochemical, microscopical and crystallographic studies led to initial phasing of data collected from ribosomal crystals at intermediate resolution. In: "Biological Structure and Dynamics, Proceedings of the 9th Conversation", (R. H. Sarma and M. H. Sarma Eds.), 25-41 (1996).

F. Schluenzen, H.A.S. Hansen, J. Thygesen, W. S. Bennett, N. Volkmann, I. Levin, J. Harms, H. Bartels, A. Zaytzev-Bashan, Z. Berkovitch-Yellin, I. Sagi, F. Franceschi, S. Krumbholz, M. Geva, S. Weinstein, I. Agmon, N. Boddeker, S. Morlang, R. Sharon, A. Dribin, E. Maltz, M. Peretz, V.Weinrich, and A. Yonath. A milestone in ribosomal crystallo-graphy: the construction of preliminary electron density maps at intermediate resolution. J. of Biochem. and Cell Biol. 73, 739-749 (1995).

J. Harms, F. Schluenzen, K. von Boehlen, J. Thygesen, S. Meyer, I. Dunkel, B. Donzelmann, H.A.S. Hansen, A. Zaytzev-Bashan, A. Dribin, G. Kryger, G. Thoms, N. Volkmann, H. Bartels, W.S. Bennett & A. Yonath. The Effect of Cryogenic Treatment on the Cell Dimensions of Ribosomal Crystals. ESF Report (K. Wilson Ed.) 26 (1993).

Disputation, Diplomarbeit

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J. Harms. Strukturelle Untersuchungen der großen ribosomalen Untereinheit von Haloarcula marismortui. Dissertation, Universität Hamburg (1999).

J. Harms. Ansätze zur Lösung des Isomorphieproblems ribosomaler Kristalle. Diplomarbeit, Universität Hamburg (1994).

Resultate nur auf Postern publiziert

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Presented at: the 43rd ICAAC, An annual meeting of the American Society for Microbiology, Chicago, September 14-17, 2003

G. Wang, Y. Qiu, D. Niu, N. H. Vo, T. Beach, A. Polemeropoulos, B. Scorneaux, A. Arya, F. Schlünzen, J.M. Harms, R. Albrecht, A. Yonath, Y. Korkhin, L. T. Phan, Y. S. Or. Design, Synthesis and Antibacterial Activities of Novel 6,11-3Carbon-Bridged Ketolides

Y. Qiu, T. Jian, N. H. Vo, Y. Hou, Z. Chen, T. Beach, A. Polemeropoulos, F. Schlünzen, J.M. Harms, R. Albrecht, A. Yonath, Y. Korkhin, L. T. Phan, Y. S. Or, Novel 4'-O-Substituted Tylosin Derivatives to Overcome Bacterial Resistance

Special Artwork

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Journal Titelbild: Konzept und Illustration, Molecular Cell, April 2008.

Journal Titelbild: Konzept und Illustration, Structure, März 2007.

1 Wochenbeitrag (Bild und Textrohfassung) sowie Bild-Bearbeitung und Textrohfassung zweier weiterer Beiträge unserer Gruppe , MPG-Tischkalender 2007.

Journal Titelbild: Konzept und Illustration, Biological Chemistry, Dezember 2005.

Bildbeiträge für verschiedene deutsche Schulbücher (2005).

4 Wochenbeiträge (Bild und Textrohfassung), MPG-Tischkalender 2005. Davon 2 gewählt als offizielle Postkartenmotive der MPG.

Titelbild: Direktorenhandbuch der Max-Planck-Gesellschaft 2004.

Ribosomenstruktur-Teil der Infobroschüre der Max-Planck-Arbeitsgruppen für strukturelle Molekularbiologie (Text zusammen mit F. Schlünzen). Mitgestaltung des generellen Layouts (2003).

Poster: Organisation, Konzept und Illustration, Cell Science at a glance - J Cell Sci, 116, 1391-93 (2003).

Journal Titelbild: Konzept und Illustration, Current Drug Targets - Infectious Disorders, Vol. 2, 169-86 (2002).

Journal Titelbild: Konzept und Illustration, Current Protein and Peptide Science, 3, 55-65, (2002).

Offizielle Beiträge (Bilder und Textrohfassung) der MPG-AG Ribosomenstruktur für die Ausstellungen 'TESLA das Licht der Zukunft’ (2001) und dem 'Science Tunnel’ der MPG anlässlich der Expo (2000).

Titel-Illustration: Max-Planck-Gesellschaft Jahrbuch 2001 (2001).

Journal Titelbild: Konzept und Illustration, Nature, 413, 814-821 (2001).

1 Wochenbeitrag (Bild und Textrohfassung), MPG-Tischkalender 2002.

Internet

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riboworld.com , private Darstellung der Forschungsergebnisse für nicht-Wissenschaftler, Schüler und Studenten.

Programmierung, Koordination, Gestaltung, Bilder, teilw. Text: Offizielle Seiten des Arbeitskreis Fucini im Excellence Cluster Makromolekulare Komplexe an der Goethe-Univ. Frankfurt a.M. ( http://user.uni-frankfurt.de/~joharms/akfucini/)

Programmierung, Koordination, Gestaltung, Bilder, teilw. Text: Offizielle Seiten der Ribosomen-Gruppe Fucini des MPI für molekulare Genetik. (über den direkten Link noch zu erreichen --> http://www.molgen.mpg.de/~ag_ribo/ag_fucini/)

Offizielle Informations-Seiten der ehemaligen Arbeitsgruppe Ribosomenstruktur der Max-Planck-Gesellschaft in Hamburg (nicht mehr im Netz).

w ww.moeckundmoeck.de (vorläufige Firmenwebsite)

Foto-Seiten Bugenhagenschule Groß-Flottbek, Hamburg (nicht öffentlich)

Links zu vielen Publikationen finden sich auf der riboworld Publikationen Seite. Bei Bedarf schicke ich auch gerne ein PDF zu.