A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine-Dalgarno interaction.
Kaminishi T.*, Wilson DN.* , Takemoto C.*, Harms JM.*, Kawazoe M., Schluenzen F., Hanawa-Suetsugu K., Shirouzu M., Fucini P. and Yokoyama S.
Structure. 2007 Mar;15(3):289-97. (PDF upon request )
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Schluenzen F, Takemoto C, Wilson DN, Kaminishi T, Harms JM, Hanawa-Suetsugu K, Szaflarski W, Kawazoe M, Shirouzu M, Nierhaus KH, Yokoyama S, Fucini P.
Nat Struct Mol Biol. 2006 Oct;13(10):871-8. Epub 2006 Sep 24. (PDF upon request )
Species-specific antibiotic-ribosome interactions: implications for drug development.
Wilson DN, Harms JM, Nierhaus KH, Schlünzen F and Fucini P.
Biological Chemistry, 386, 12, Dec. 2005. (PDF upon request )
The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction
Frank Schlünzen, Daniel N. Wilson, Pingsheng Tian, Jörg M. Harms, Stuart J. McInnes, Harly A.S. Hansen, Renate Albrecht, Jörg Buerger, Sigurd M. Wilbanks, and Paola Fucini. Structure, Vol 13, 1685-1694, November 2005. (PDF upon request )
Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation. Mihaela Diaconu*, Ute Kothe*, Frank Schlünzen, Niels Fischer, Jörg M. Harms, Alexander G. Tonevitsky, Holger Stark, Marina V. Rodnina, >and Markus C. Wahl. Cell, Vol 121, 991-1004, 1 July 2005 (PDF upon request )
X-ray Crystallography on Ribosome Recycling: Mechanism of Binding & Action of RRF on the 50S Subunit.
DN. Wilson*, F. Schluenzen,* J.M. Harms*, T. Yoshida, T. Ohkubo, R. Albrecht, J. Buerger, Y. Kobayashi and P. Fucini. EMBO J. 2005 Jan 26;24(2):251-60. Epub 2004 Dec 23. (PDF upon request)
Inhibition of Peptide Bond Formation by Pleuromutilins: the Structure of the 50S Ribosomal Subunit from Deinococcus radiodurans in Complex with Tiamulin F. Schlünzen, E. Pyetan, P. Fucini, A. Yonath and J.M. Harms. Molecular Microbiology, 54(5), 1287-1294, 2004. (PDF upon request)
Alterations at the petidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin. J.M. Harms*, F. Schlünzen*, P. Fucini, H. Bartels and A. Yonath. BMCBiology , 2:4 , April 2004 (open access) (PDF)
Structural insight into the dynamic role of the ribosomal tunnel in cellular regulation.
R. Berisio, F. Schlünzen, J. Harms, A. Bashan, T. Auerbach, D. Baram and A. Yonath. Nature Structural Biology, 10(5), 366-370, 2003. (PDF)
# Antibiotic Action On The Translational Apparatus.
J.M. Harms, H. Bartels, F. Schlünzen and A. Yonath. J.Cell.Sci.,116, 1391-1393 (2003). (PDF)
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Structural basis for the antibiotic activity of ketolides and azalides.
F. Schlünzen*, J.M. Harms*, F. Franceschi, H.A.S. Hansen, H. Bartels, R. Zarivach and A. Yonath. Structure , 11, 329-338 (2003). (PDF upon request)
Structural Basis for Peptidyl Transferase Activity and Inhibition by Puromycin and Sparsomycin
A. Bashan, R. Zarivach, I. Agmon, F. Schlünzen, J. Harms, H. Bartels, F. Franceschi, H.A.S. Hansen, E. Kossoy, M. Kessler and A. Yonath. Mol.Cell, 11, (2003) .
PDF upon request
J. Harms*, F. Schluenzen*, R. Zarivach*, A. Bashan, S. Gat, I. Agmon, H. Bartels, F. Franceschi & A. Yonath, High resolution structure of the large ribosomal subunit from a mesophilic eubacterium. Cell, 107, 679-688 (2001).
F. Schluenzen*, R. Zarivach*, J. Harms*, A. Bashan, A. Tocilj, R. Albrecht, A. Yonath and F. Franceschi, Structural basis for the interaction of antibiotics with the peptidyl transferase center in eubacteria. Nature, 413, 814-821 (2001).
M. Pioletty*, F. Schluenzen*, J. Harms*, M. Gluehmann, R. Zarivach, A. Bashan, H. Bartels, T. Auerbach, F. Franceschi and A.Yonath. The crystal structure of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J., 20, 1829-1839 (2001).
F. Schluenzen*, A. Tocilj*, R. Zarivach, J. Harms, M. Gluehmann, D. Janell, A. Bashan, H. Bartels, I. Agmon, F. Franceschi & A. Yonath. Structure of a functionally activated small ribosomal subunit at 3.3 A resolution. Cell, 102, 615-623 (2000).
J. Harms, F. Schluenzen, K. von Boehlen, J. Thygesen, S. Meyer, I. Dunkel, B. Donzelmann, H.A.S. Hansen, A. Zaytzev-Bashan, A. Dribin, G. Kryger, G. Thoms, N. Volkmann, H. Bartels, W. S. Bennett & A. Yonath. The Effect of Cryogenic Treatment on the Cell Dimensions of Ribosomal Crystals. ESF Report (K. Wilson Ed.) 26 (1993).
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